A 45-year-old male with new onset Atrial Fibrillation and no past medical history should be prescribed which medication?

In the case of a 45-year-old male with new onset atrial fibrillation and no past medical history, prescribing aspirin (ASA) is an appropriate choice as an initial management strategy. Atrial fibrillation increases the risk of thromboembolism, particularly stroke, due to irregular blood flow through the heart. Anticoagulation therapy is often required for those at higher risk based on various factors such as age and comorbidities.

In the absence of significant risk factors or a high CHADS2 or CHA2DS2-VASc score, aspirin can be utilized. It provides some level of stroke prophylaxis without the increased bleeding risks associated with stronger anticoagulants like warfarin (Coumadin) or direct oral anticoagulants, which may be more suitable based on risk stratification.

While Coumadin is a strong anticoagulant, it generally requires monitoring and is typically reserved for patients with higher risks or those with specific considerations. Plavix is an antiplatelet medication and is not the first-line treatment for atrial fibrillation although it may play a role post-stroke or in stent patients.

Therefore, in the context of this patient with new onset atrial fibrillation, the rationale