In a patient with a history of cardiovascular disease and worsening knee pain, which medication is contraindicated?

In the context of a patient with a history of cardiovascular disease, celecoxib is contraindicated primarily due to its association with an increased risk of cardiovascular events such as heart attacks or stroke. Celecoxib is a selective COX-2 inhibitor, and while it may have some advantages in terms of gastrointestinal safety compared to non-selective NSAIDs, its cardiovascular risks are significant, especially in individuals with preexisting conditions.

Patients with cardiovascular disease need to be cautious with any medication that could exacerbate their condition, and given that celecoxib can promote cardiovascular complications, it is advisable to avoid this medication in this patient population to minimize the risk of adverse effects.

Other options, such as ibuprofen and aspirin, may be used with caution, depending on the overall clinical picture and monitoring for potential risks. Acetaminophen is generally considered a safer alternative for pain relief in patients with cardiovascular concerns as it does not have the same cardiovascular risks associated with COX-2 inhibitors.