What is a key hallmark symptom of thyroid storm?

Fever is considered a key hallmark symptom of thyroid storm due to the hypermetabolic state induced by significantly elevated levels of thyroid hormones. In cases of thyroid storm, patients can experience severe elevations in body temperature, often exceeding 101°F (38.3°C) and can even reach as high as 104°F (40°C) or more. This hyperthermic response is the result of an increased metabolic rate; the body's processes become hyperactive, leading to heightened thermogenesis.

Thyroid storm is a life-threatening condition that can occur in patients with untreated hyperthyroidism or those with a precipitating event such as surgery, infection, or trauma. Along with fever, other symptoms of thyroid storm may include tachycardia, agitation or delirium, nausea, vomiting, and profuse sweating. Recognizing fever as a primary sign is critical for prompt diagnosis and management of this emergency condition to prevent complications and improve outcomes.