What is a side effect of levothyroxine that may lead to non-compliance when first initiated?

Alopecia is a known side effect of levothyroxine that can contribute to non-compliance, particularly when the medication is first initiated. In many cases, patients may not expect or want hair loss as a consequence of starting a thyroid hormone replacement therapy, which could lead to a reluctance to continue taking the medication.

Levothyroxine is primarily prescribed to treat hypothyroidism by supplementing inadequate thyroid hormone levels. While weight loss, nervousness, and dyspepsia may occur in some patients, they are less commonly discussed in relation to immediate non-compliance. Alopecia, however, can distinctly affect a person's self-image and emotional well-being, prompting some patients to abandon their treatment due to the distress it causes. Thus, understanding this side effect is crucial for healthcare providers when counseling patients on levothyroxine therapy and managing their expectations.