Which diagnostic test is definitive for confirming pheochromocytoma?

The definitive diagnostic test for confirming pheochromocytoma is Computed Tomography (CT). This condition generally involves a tumor of the adrenal gland that produces excessive catecholamines, leading to symptoms such as hypertension, palpitations, and sweating. CT imaging is particularly useful because it provides detailed cross-sectional images of the adrenal glands and surrounding structures, allowing for the identification of tumors based on size, location, and morphology.

CT scans have a high sensitivity and specificity for detecting pheochromocytomas, making them an essential tool in establishing a diagnosis when a clinician suspects this condition based on clinical signs and laboratory findings, such as elevated plasma free metanephrines or urinary catecholamines. The ability of CT to visualize adrenal masses more clearly than other non-invasive imaging options allows for a definitive diagnosis.

While MRI can also be used and is especially beneficial in certain situations (like in patients with contraindications to CT contrast), CT is generally considered the first-line imaging modality for the evaluation of suspected pheochromocytoma. Additionally, abdominal ultrasound is not typically definitive for this diagnosis, as it may not provide enough detail or may miss smaller tumors. Blood glucose testing does not pertain to the diagnosis of pheochromocytoma, as this condition