Which is a common adverse effect of methotrexate therapy?

Methotrexate is commonly used as a disease-modifying antirheumatic drug (DMARD) and in cancer treatment, and one of its notable adverse effects is liver toxicity. This risk arises because methotrexate is metabolized in the liver, and elevated liver enzymes can indicate hepatotoxicity, particularly with higher doses or prolonged use. Regular monitoring of liver function tests is essential for patients on methotrexate therapy to detect any emerging liver toxicity early on.

Although methotrexate can also cause other adverse effects, such as kidney damage, hair loss, and gastrointestinal disturbances, liver toxicity is particularly significant due to its potential severity and the need for ongoing assessment in patients receiving this therapy.